Regulation of Multidrug Resistance Proteins by Genistein in a Hepatocarcinoma Cell Line: Impact on Sorafenib Cytotoxicity

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide. Sorafenib is the only drug available that improves the overall survival of HCC patients. P-glycoprotein (P-gp), Multidrug resistance-associated proteins 2 and 3 (MRP2 and 3) and Breast cancer resistance protein (BCRP) are ef...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rigalli, Juan Pablo, Ciriaci, Nadia, Arias, Agostina, Ceballos, María Paula, Villanueva, Silvina Stella Maris, Luquita, Marcelo Gabriel, Mottino, Aldo Domingo, Ghanem, Carolina Inés, Catania, Viviana Alicia, Ruiz, María Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364073/
https://ncbi.nlm.nih.gov/pubmed/25781341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119502
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