Induction of Hepatic Multidrug Resistance-Associated Protein 3 by Ethynylestradiol Is Independent of Cholestasis and Mediated by Estrogen Receptor

Multidrug resistance–associated protein 3 (Mrp3; Abcc3) expression and activity are up-regulated in rat liver after in vivo repeated administration of ethynylestradiol (EE), a cholestatic synthetic estrogen, whereas multidrug resistance-associated protein 2 (Mrp2) is down-regulated. This study was u...

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Bibliographic Details
Main Authors: Ruiz, María L., Rigalli, Juan P., Arias, Agostina, Villanueva, Silvina, Banchio, Claudia, Vore, Mary, Mottino, Aldo D., Catania, Viviana A.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
Subjects:
Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558861/
https://ncbi.nlm.nih.gov/pubmed/23077105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.047357
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