Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor

BACKGROUND: Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and transporter proteins has not been studied yet. METHODOLOGY/PRINCIPAL FINDINGS: Expression and activity of P-glycoprotein (P-gp), Multid...

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Detaylı Bibliyografya
Asıl Yazarlar: Rigalli, Juan P., Perdomo, Virginia G., Luquita, Marcelo G., Villanueva, Silvina S. M., Arias, Agostina, Theile, Dirk, Weiss, Johanna, Mottino, Aldo D., Ruiz, María L., Catania, Viviana A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521711/
https://ncbi.nlm.nih.gov/pubmed/23272261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001951
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