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Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole
The effect of benznidazole (BZL) on the expression and activity of P-glycoprotein (P-gp, ABCB1) and multidrug resistance-associated protein 2 (MRP2, ABCC2), the two major transporters of endogenous and exogenous compounds, was evaluated in differentiated THP-1 cells. BZL induced P-gp and MRP2 protei...
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| Publicado no: | Mem Inst Oswaldo Cruz |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Instituto Oswaldo Cruz, Ministério da Saúde
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5125048/ https://ncbi.nlm.nih.gov/pubmed/27783718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760160080 |
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