Inhibition of KIT-Glycosylation by 2-Deoxyglucose Abrogates KIT-Signaling and Combination with ABT-263 Synergistically Induces Apoptosis in Gastrointestinal Stromal Tumor

Positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) is frequently used for visualizing gastrointestinal stromal tumors (GIST), which are highly glucose-avid tumors. Dramatic metabolic responses following imatinib treatment indicate a high, KIT-dependent glucose turnover which has...

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Опубликовано в: :PLoS One
Главные авторы: Mühlenberg, Thomas, Grunewald, Susanne, Treckmann, Jürgen, Podleska, Lars, Schuler, Martin, Fletcher, Jonathan A., Bauer, Sebastian
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364009/
https://ncbi.nlm.nih.gov/pubmed/25781619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120531
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