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ABT-263 Enhances Sensitivity to Metformin and 2-Deoxyglucose in Pediatric Glioma by Promoting Apoptotic Cell Death

Pediatric high grade glioma is refractory to conventional multimodal treatment, highlighting a need to develop novel efficacious therapies. We investigated tumor metabolism as a potential therapeutic target in a panel of diverse pediatric glioma cell lines (SF188, KNS42, UW479 and RES186) using metf...

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Autors principals: Levesley, Jane, Steele, Lynette, Taylor, Claire, Sinha, Priyank, Lawler, Sean E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656874/
https://ncbi.nlm.nih.gov/pubmed/23691145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064051
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