iPLA(2)• Knockout Mouse, a Genetic Model for Progressive Human Motor Disorders, Develops Age-Related Neuropathology

Calcium-independent phospholipase A(2) group VIa (iPLA(2)β) preferentially releases docosahexaenoic acid (DHA) from the sn-2 position of phospholipids. Mutations of its gene, PLA2G6, are found in patients with several progressive motor disorders, including Parkinson disease. At 4 months, PLA2G6 knoc...

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Detalhes bibliográficos
Publicado no:Neurochem Res
Main Authors: Blanchard, Helene, Taha, Ameer Y., Cheon, Yewon, Kim, Hyung-Wook, Turk, John, Rapoport, Stanley I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364003/
https://ncbi.nlm.nih.gov/pubmed/24919816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-014-1342-y
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