Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells

The immune mechanisms regulating epithelial cell repair after injury remain poorly defined. We demonstrate here that lymphotoxin beta receptor (LTβR) signaling in intestinal epithelial cells promotes self-repair after mucosal damage. Using a conditional gene-targeted approach, we demonstrate that LT...

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Bibliographic Details
Published in:Mucosal Immunol
Main Authors: Macho-Fernandez, Elise, Koroleva, Ekaterina P., Spencer, Cody M., Tighe, Michael, Torrado, Egidio, Cooper, Andrea M., Fu, Yang-Xin, Tumanov, Alexei V.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364000/
https://ncbi.nlm.nih.gov/pubmed/25183367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.78
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