Identification and Characterization of PERK Activators by Phenotypic Screening and Their Effects on NRF2 Activation

Endoplasmic reticulum stress plays a critical role to restore the homeostasis of protein production in eukaryotic cells. This vital process is hence involved in many types of diseases including COPD. PERK, one branch in the ER stress signaling pathways, has been reported to activate NRF2 signaling p...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Xie, Wensheng, Pariollaud, Marie, Wixted, William E., Chitnis, Nilesh, Fornwald, James, Truong, Maggie, Pao, Christina, Liu, Yan, Ames, Robert S., Callahan, James, Solari, Roberto, Sanchez, Yolanda, Diehl, Alan, Li, Hu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363567/
https://ncbi.nlm.nih.gov/pubmed/25780921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119738
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