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Generation and characterization of an analog-sensitive PERK allele

Restriction of nutrients and oxygen in the tumor microenvironment disrupts ER homeostasis and adaptation to such stress is mediated by the key UPR effector PERK. Given its pro-tumorigenic activity, significant efforts have been made to elucidate the molecular mechanisms that underlie PERK function....

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Bibliografske podrobnosti
Main Authors: Maas, Nancy L, Singh, Nickpreet, Diehl, J Alan
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119078/
https://ncbi.nlm.nih.gov/pubmed/24846185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29274
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