Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations

Human PRS1, which is indispensable for the biosynthesis of nucleotides, deoxynucleotides and their derivatives, is associated directly with multiple human diseases because of single base mutation. However, a molecular understanding of the effect of these mutations is hampered by the lack of understa...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chen, Peng, Liu, Zheng, Wang, Xuejuan, Peng, Junhui, Sun, Qianqian, Li, Jianzhong, Wang, Mingxing, Niu, Liwen, Zhang, Zhiyong, Cai, Gang, Teng, Maikun, Li, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363470/
https://ncbi.nlm.nih.gov/pubmed/25781187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120304
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