Dual Specificity Phosphatase 6 (DUSP6) regulates CD4+ T cell functions and restrains the spontaneous colitis in IL-10 deficient mice

Mitogen-activated protein kinase (MAPK) phosphatases are dual-specificity phosphatases (DUSPs) that dephosphorylate phosphothreonine and phosphotyrosine residues within MAPKs. DUSP6 preferentially dephosphorylates extracellular signal-regulated kinase 1 and 2 (ERK1/2) rendering them inactive. Here,...

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Udgivet i:Mucosal Immunol
Main Authors: Bertin, Samuel, Lozano-Ruiz, Beatriz, Bachiller, Victoria, García-Martínez, Irma, Herdman, Scott, Zapater, Pedro, Francés, Rubén, Such, José, Lee, Jongdae, Raz, Eyal, González-Navajas, José M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363301/
https://ncbi.nlm.nih.gov/pubmed/25227984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.84
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