Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine

Keratitis-ichthyosis-deafness (KID) syndrome is an ectodermal dysplasia caused by dominant mutations of connexin26 (Cx26). Loss of Cx26 function causes non-syndromic sensorineural deafness, without consequence in the epidermis. Functional analyses have revealed that a majority of KID-causing mutatio...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Levit, Noah A., Sellitto, Caterina, Wang, Hong-Zhan, Li, Leping, Srinivas, Miduturu, Brink, Peter R., White, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363291/
https://ncbi.nlm.nih.gov/pubmed/25229253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2014.408
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