Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils

Recent evidence suggests that neutrophils play an important role in the pathogenesis of lupus. The goal of this study was to characterize the epigenetic architecture, by studying the DNA methylome, of neutrophils and low density granulocytes (LDGs) in lupus patients. We studied 15 lupus patients and...

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Publicado en:J Autoimmun
Autores principales: Coit, Patrick, Yalavarthi, Srilakshmi, Ognenovski, Mikhail, Zhao, Wenpu, Hasni, Sarfaraz, Wren, Jonathan D., Kaplan, Mariana J., Sawalha, Amr H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363276/
https://ncbi.nlm.nih.gov/pubmed/25638528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.01.004
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