Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity

Noscapine, an opium-derived ‘kinder-gentler’ microtubule-modulating drug is in Phase I/II clinical trials for cancer chemotherapy. However, its limited water solubility encumbers its development into an oral anticancer drug with clinical promise. Here we report the synthesis of 9 third-generation, w...

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Udgivet i:Biochem Pharmacol
Main Authors: Henary, Maged, Narayana, Lakshminarayana, Ahad, Shazia, Gundala, Sushma R., Mukkavilli, Rao, Sharma, Vibhuti, Owens, Eric A., Yadav, Yogesh, Nagaraju, Mulpuri, Hamelberg, Donald, Tandon, Vibha, Panda, Dulal, Aneja, Ritu
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363136/
https://ncbi.nlm.nih.gov/pubmed/25124704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.07.020
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