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The Use of Pseudo-equilibrium Constant Affords Improved QSAR Models of Human Plasma Protein Binding
PURPOSE: To develop accurate in silico predictors of Plasma Protein Binding (PPB). METHODS: Experimental PPB data were compiled for over 1,200 compounds. Two endpoints have been considered: (1) fraction bound (%PPB); and (2) the logarithm of a pseudo binding constant (lnKa) derived from %PPB. The la...
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| Publié dans: | Pharm Res |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4363124/ https://ncbi.nlm.nih.gov/pubmed/23568522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-1023-6 |
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