QSAR Development for Plasma Protein Binding: Influence of the Ionization State

PURPOSE: This study explored several strategies to improve the performance of literature QSAR models for plasma protein binding (PPB), such as a suitable endpoint transformation, a correct representation of chemicals, more consistency in the dataset, and a reliable definition of the applicability do...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharm Res
Hauptverfasser: Toma, Cosimo, Gadaleta, Domenico, Roncaglioni, Alessandra, Toropov, Andrey, Toropova, Alla, Marzo, Marco, Benfenati, Emilio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6308215/
https://ncbi.nlm.nih.gov/pubmed/30591975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2561-8
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge