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Use of in Vitro HTS-Derived Concentration–Response Data as Biological Descriptors Improves the Accuracy of QSAR Models of in Vivo Toxicity

BACKGROUND: Quantitative high-throughput screening (qHTS) assays are increasingly being used to inform chemical hazard identification. Hundreds of chemicals have been tested in dozens of cell lines across extensive concentration ranges by the National Toxicology Program in collaboration with the Nat...

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Библиографические подробности
Главные авторы: Sedykh, Alexander, Zhu, Hao, Tang, Hao, Zhang, Liying, Richard, Ann, Rusyn, Ivan, Tropsha, Alexander
Формат: Artigo
Язык:Inglês
Опубликовано: National Institute of Environmental Health Sciences 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060000/
https://ncbi.nlm.nih.gov/pubmed/20980217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1002476
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