Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of Acidic Fibroblast Growth Factor

Fibroblast growth factor 1 (FGF1) is a heparin-binding proangiogenic protein. FGF1 lacks the conventional N-terminal signal peptide required for secretion through the endoplasmic reticulum (ER) -Golgi secretory pathway. FGF1 is released through a Cu(2+) - mediated nonclassical secretion pathway. The...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Jayanthi, Srinivas, Kathir, Karuppanan Muthusamy, Rajalingam, Dakshinamurthy, Furr, Mercede, Daily, Anna, Thurman, Ryan, Rutherford, Lindsay, Chandrashekar, Reena, Adams, Paul, Prudovsky, Igor, Suresh Kumar, Thallapuranam Krishnaswamy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362929/
https://ncbi.nlm.nih.gov/pubmed/25224745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2014.09.008
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