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Influence of Pathogenic Mutations on the Energetics of Translocon-Mediated Bilayer Integration of Transmembrane Helices

Aberrant protein folding and assembly contribute to a number of diseases, and efforts to rationalize how pathogenic mutations cause this phenomenon represent an important imperative in biochemical research. However, for α-helical membrane proteins, this task is complicated by the fact that membrane...

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Detalhes bibliográficos
Publicado no:J Membr Biol
Main Authors: Schlebach, Jonathan P., Sanders, Charles R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362857/
https://ncbi.nlm.nih.gov/pubmed/25192979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-014-9726-0
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