Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide

Hypokalemia is a recognized adverse effect of thiazide diuretic treatment. This phenomenon, which may impair insulin secretion, has been suggested to be a reason for the adverse effects on glucose metabolism associated with thiazide diuretic treatment of hypertension. However, the mechanisms underly...

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Bibliographic Details
Published in:Pharmacogenomics J
Main Authors: Del-Aguila, Jorge L., Cooper-DeHoff, Rhonda M., Chapman, Arlene B., Gums, John G., Beitelshees, Amber L., Bailey, Kent, Turner, Stephen T., Johnson, Julie A., Boerwinkle, Eric
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362777/
https://ncbi.nlm.nih.gov/pubmed/25201287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2014.46
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