Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies(1). Genome-wide association studies (GWAS)(2)...

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Veröffentlicht in:Nat Med
Hauptverfasser: Xing, Luzhou, Dai, Zhenpeng, Jabbari, Ali, Cerise, Jane E, Higgins, Claire A, Gong, Weijuan, de Jong, Annemieke, Harel, Sivan, DeStefano, Gina M, Rothman, Lisa, Singh, Pallavi, Petukhova, Lynn, Mackay-Wiggan, Julian, Christiano, Angela M, Clynes, Raphael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362521/
https://ncbi.nlm.nih.gov/pubmed/25129481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3645
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