A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication

Hepatitis C virus (HCV) infection is a leading cause of liver disease worldwide. The HCV RNA genome is translated into a single polyprotein. Most of the cleavage sites in the non-structural (NS) polyprotein region are processed by the NS3/NS4A serine protease. The vital NS2-NS3 cleavage is catalyzed...

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Publicado en:PLoS Pathog
Autores principales: Isken, Olaf, Langerwisch, Ulrike, Jirasko, Vlastimil, Rehders, Dirk, Redecke, Lars, Ramanathan, Harish, Lindenbach, Brett D., Bartenschlager, Ralf, Tautz, Norbert
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361677/
https://ncbi.nlm.nih.gov/pubmed/25774920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004736
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