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Supervillin Binds the Rac/Rho-GEF Trio and Increases Trio-mediated Rac1 Activation

We investigated cross-talk between the membrane-associated, myosin II-regulatory protein supervillin and the actin-regulatory small GTPases Rac1, RhoA, and Cdc42. Supervillin knockdown reduced Rac1-GTP loading, but not the GTP loading of RhoA or Cdc42, in HeLa cells with normal levels of the Rac1-ac...

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Bibliografiske detaljer
Udgivet i:Cytoskeleton (Hoboken)
Main Authors: Son, Kyonghee, Smith, Tara C., Luna, Elizabeth J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361246/
https://ncbi.nlm.nih.gov/pubmed/25655724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cm.21210
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