Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9

Loss of neurons that express the neuropeptide hypocretin (Hcrt) has been implicated in narcolepsy, a debilitating disorder characterized by excessive daytime sleepiness and cataplexy. Cell replacement therapy, using Hcrt-expressing neurons generated in vitro, is a potentially useful therapeutic appr...

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Publicado en:Development
Autores principales: Liu, Justin, Merkle, Florian T., Gandhi, Avni V., Gagnon, James A., Woods, Ian G., Chiu, Cindy N., Shimogori, Tomomi, Schier, Alexander F., Prober, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360184/
https://ncbi.nlm.nih.gov/pubmed/25725064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.117424
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