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Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM
[Image: see text] Novel acetylenyl-containing benzamide derivatives were synthesized and screened using an in vitro assay measuring increases in glucokinase activity stimulated by 10 mM glucose concentration and glucose uptake in rat hepatocytes. Lead optimization of an acetylenyl benzamide series l...
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| Udgivet i: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2015
|
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4360162/ https://ncbi.nlm.nih.gov/pubmed/25815149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5004712 |
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