Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ

[Image: see text] The bacterial cell division protein FtsZ is one of many potential targets for the development of novel antibiotics. Recently, zantrin Z3 was shown to be a cross-species inhibitor of FtsZ; however, its specific interactions with the protein are still unknown. Herein we report the sy...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Nepomuceno, Gabriella M., Chan, Katie M., Huynh, Valerie, Martin, Kevin S., Moore, Jared T., O’Brien, Terrence E., Pollo, Luiz A. E., Sarabia, Francisco J., Tadeus, Clarissa, Yao, Zi, Anderson, David E., Ames, James B., Shaw, Jared T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360151/
https://ncbi.nlm.nih.gov/pubmed/25815151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500497s
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