Comparison of Small Molecule Inhibitors of the Bacterial Cell Division Protein FtsZ and Identification of a Reliable Cross-Species Inhibitor

FtsZ is a guanosine triphosphatase (GTPase) that mediates cytokinesis in bacteria. FtsZ is homologous in structure to eukaryotic tubulin and polymerizes in a similar head-to-tail fashion. The study of tubulin’s function in eukaryotic cells has benefited greatly from specific and potent small molecul...

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Bibliografski detalji
Glavni autori: Anderson, David E., Kim, Michelle B., Moore, Jared T., O’Brien, Terrence E., Sorto, Nohemy A., Grove, Charles I., Lackner, Laura L., Ames, James B., Shaw, Jared T.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514448/
https://ncbi.nlm.nih.gov/pubmed/22958099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300340j
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