Ca(2+) entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance

Ubiquitously expressed Trpm2 channel limits oxidative stress and preserves mitochondrial function. We first demonstrated that intracellular Ca(2+) concentration increase after Trpm2 activation was due to direct Ca(2+) influx and not indirectly via reverse Na(+)/Ca(2+) exchange. To elucidate whether...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Hoffman, Nicholas E., Miller, Barbara A., Wang, JuFang, Elrod, John W., Rajan, Sudasan, Gao, Erhe, Song, Jianliang, Zhang, Xue-Qian, Hirschler-Laszkiewicz, Iwona, Shanmughapriya, Santhanam, Koch, Walter J., Feldman, Arthur M., Madesh, Muniswamy, Cheung, Joseph Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2015
Témata:
Integrative Cardiovascular Physiology and Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360055/
https://ncbi.nlm.nih.gov/pubmed/25576627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00720.2014
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