Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β(1)-integrin endocytosis

Podocyte-endothelial cell cross-talk is paramount for maintaining the filtration barrier. The present study investigated the endothelial response to podocyte injury and its subsequent role in glomerulosclerosis using the podocyte-specific injury model of NEP25/LMB2 mice. NEP25/LMB2 mice showed prote...

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Vydáno v:Am J Physiol Renal Physiol
Hlavní autoři: Kobayashi, Namiko, Ueno, Toshiharu, Ohashi, Kumi, Yamashita, Hanako, Takahashi, Yukina, Sakamoto, Kazuo, Manabe, Shun, Hara, Satoshi, Takashima, Yasutoshi, Dan, Takashi, Pastan, Ira, Miyata, Toshio, Kurihara, Hidetake, Matsusaka, Taiji, Reiser, Jochen, Nagata, Michio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360033/
https://ncbi.nlm.nih.gov/pubmed/25587125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00616.2014
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