Cyclin C stimulates β-cell proliferation in rat and human pancreatic β-cells

Activation of pancreatic β-cell proliferation has been proposed as an approach to replace reduced functional β-cell mass in diabetes. Quiescent fibroblasts exit from G0 (quiescence) to G1 through pRb phosphorylation mediated by cyclin C/cdk3 complexes. Overexpression of cyclin D1, D2, D3, or cyclin...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Jiménez-Palomares, Margarita, López-Acosta, José Francisco, Villa-Pérez, Pablo, Moreno-Amador, José Luis, Muñoz-Barrera, Jennifer, Fernández-Luis, Sara, Heras-Pozas, Blanca, Perdomo, Germán, Bernal-Mizrachi, Ernesto, Cózar-Castellano, Irene
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360017/
https://ncbi.nlm.nih.gov/pubmed/25564474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00260.2014
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