Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism

Early cognitive impairment in Alzheimer's disease (AD) correlates with medial temporal lobe dysfunction, including two areas essential for memory formation: the entorhinal cortex and dentate gyrus (DG). In the Tg2576 animal model for AD amyloidosis, activation of the peroxisome proliferator-act...

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Detalles Bibliográficos
Publicado en:J Neurophysiol
Autores principales: Nenov, Miroslav N., Tempia, Filippo, Denner, Larry, Dineley, Kelly T., Laezza, Fernanda
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2014
Materias:
Cellular and Molecular Properties of Neurons
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359997/
https://ncbi.nlm.nih.gov/pubmed/25540218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00419.2014
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