Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism

Early cognitive impairment in Alzheimer's disease (AD) correlates with medial temporal lobe dysfunction, including two areas essential for memory formation: the entorhinal cortex and dentate gyrus (DG). In the Tg2576 animal model for AD amyloidosis, activation of the peroxisome proliferator-act...

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Dades bibliogràfiques
Publicat a:J Neurophysiol
Autors principals: Nenov, Miroslav N., Tempia, Filippo, Denner, Larry, Dineley, Kelly T., Laezza, Fernanda
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2014
Matèries:
Cellular and Molecular Properties of Neurons
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359997/
https://ncbi.nlm.nih.gov/pubmed/25540218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00419.2014
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