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Cognitive Enhancing Treatment with a PPARγ Agonist Normalizes Dentate Granule Cell Presynaptic Function in Tg2576 APP Mice

Hippocampal network hyperexcitability is considered an early indicator of Alzheimer's disease (AD) memory impairment. Some AD mouse models exhibit similar network phenotypes. In this study we focused on dentate gyrus (DG) granule cell spontaneous and evoked properties in 9-month-old Tg2576 mice...

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Библиографические подробности
Главные авторы: Nenov, Miroslav N., Laezza, Fernanda, Haidacher, Sigmund J., Zhao, Yingxin, Sadygov, Rovshan G., Starkey, Jonathan M., Spratt, Heidi, Luxon, Bruce A., Dineley, Kelly T., Denner, Larry
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891946/
https://ncbi.nlm.nih.gov/pubmed/24431460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3413-13.2014
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