Poxvirus Decapping Enzymes Enhance Virulence by Preventing the Accumulation of dsRNA and the Induction of Innate Antiviral Responses

Poxvirus replication involves synthesis of double stranded RNA (dsRNA), which can trigger antiviral responses by inducing phosphorylation-mediated activation of protein kinase R (PKR) and stimulating 2’5’-oligoadenylate synthetase (OAS). PKR inactivates the translation initiation factor eIF2α via ph...

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Bibliografiske detaljer
Udgivet i:Cell Host Microbe
Main Authors: Liu, Shin-Wu, Katsafanas, George C., Liu, Ruikang, Wyatt, Linda S., Moss, Bernard
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359750/
https://ncbi.nlm.nih.gov/pubmed/25766293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.02.002
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