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The D10 Decapping Enzyme of Vaccinia Virus Contributes to Decay of Cellular and Viral mRNAs and to Virulence in Mice

Posttranscriptional mechanisms are important for regulation of cellular and viral gene expression. The presence of the 5′ cap structure m(7)G(5′)ppp(5′)Nm is a general feature of mRNAs that provides protection from exoribonuclease digestion and enhances translation. Vaccinia virus and other poxvirus...

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Autores principales: Liu, Shin-Wu, Wyatt, Linda S., Orandle, Marlene S., Minai, Mahnaz, Moss, Bernard
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911708/
https://ncbi.nlm.nih.gov/pubmed/24155373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02426-13
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