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Development of a new approach for targeted gene editing in primordial germ cells using TALENs in Xenopus

A gene of interest can be efficiently modified using transcription activator-like effector nucleases (TALENs) (Christian et al., 2010;Li et al., 2011). However, if a target gene is essential for development, growth and fertility, use of TALENs with high mutagenic activity in F0 frogs could result in...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biol Open
Main Authors: Nakajima, Keisuke, Yaoita, Yoshio
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359732/
https://ncbi.nlm.nih.gov/pubmed/25661867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.201410926
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