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Zygotic Genome Activation Triggers the DNA Replication Checkpoint at the Midblastula Transition

A conserved feature of the midblastula transition (MBT) is a requirement for a functional DNA replication checkpoint to coordinate cell cycle remodeling and zygotic genome activation (ZGA). We have investigated what triggers this checkpoint during Drosophila embryogenesis. We find that the magnitude...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell
Prif Awduron: Blythe, Shelby A., Wieschaus, Eric F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359640/
https://ncbi.nlm.nih.gov/pubmed/25748651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.01.050
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