Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma

Targeting reprogrammed energy metabolism such as aerobic glycolysis is a potential strategy for cancer treatment. However, tumors exhibiting low-rate glycolysis or metabolic heterogeneity might be resistant to such treatment. We hypothesized that a therapeutic modality that drove cancer cells to hig...

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Foilsithe in:Oncotarget
Main Authors: Li, Chunyan, Meng, Gang, Su, Lei, Chen, Aiping, Xia, Mao, Xu, Chun, Yu, Decai, Jiang, Aiqin, Wei, Jiwu
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2014
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359313/
https://ncbi.nlm.nih.gov/pubmed/25575816
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