HS-543 induces apoptosis of Imatinib-resistant chronic myelogenous leukemia with T315I mutation

Chronic myeloid leukemia (CML) is characterized by a constitutive activation of Bcr-Abl tyrosine kinase. Bcr-Abl/T315I is the predominant mutation that causes resistance to Imatinib. In the present study, we synthesized a novel Bcr-Abl inhibitor, HS-543, and investigated its effect on cell survival...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kim, Soo Jung, Jung, Kyung Hee, Yan, Hong Hua, Son, Mi Kwon, Fang, Zhenghuan, Ryu, Ye-Lim, Lee, Hyunseung, Lim, Joo Han, Suh, Jun-Kyu, Kim, JinHee, Lee, Soyoung, Hong, Sungwoo, Hong, Soon-Sun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359310/
https://ncbi.nlm.nih.gov/pubmed/25483100
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