Synthetic Aβ peptides acquire prion-like properties in the brain

In transmission studies with Alzheimer's disease (AD) animal models, the formation of Aβ plaques is proposed to be initiated by seeding the inoculated amyloid β (Aβ) peptides in the brain. Like the misfolded scrapie prion protein (PrP(Sc)) in prion diseases, Aβ in AD shows a certain degree of r...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Xiao, Xiangzhu, Cali, Ignazio, Yuan, Jue, Cracco, Laura, Curtiss, Paul, Zeng, Liang, Abouelsaad, Mai, Gazgalis, Dimitris, Wang, Gong-Xian, Kong, Qingzhong, Fujioka, Hisashi, Puoti, Gianfranco, Zou, Wen-Quan
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2014
Assuntos:
Gerotarget (Focus on Aging): Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359245/
https://ncbi.nlm.nih.gov/pubmed/25460507
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