Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells

Dormant or slow-cycling disseminated tumor cells (DTCs) in bone marrow (BM) are resistant to conventional therapy in various cancers including head and neck squamous cell carcinoma (HNSCC), although the molecular mechanisms remain largely unknown. This study aimed to identify the intrinsic molecular...

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Опубликовано в: :Oncotarget
Главные авторы: Nakamura, Takuya, Shinriki, Satoru, Jono, Hirofumi, Guo, Jianying, Ueda, Mitsuharu, Hayashi, Mitsuhiro, Yamashita, Satoshi, Zijlstra, Andries, Nakayama, Hideki, Hiraki, Akimitsu, Shinohara, Masanori, Ando, Yukio
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2014
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359213/
https://ncbi.nlm.nih.gov/pubmed/25504440
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