Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells

Dormant or slow-cycling disseminated tumor cells (DTCs) in bone marrow (BM) are resistant to conventional therapy in various cancers including head and neck squamous cell carcinoma (HNSCC), although the molecular mechanisms remain largely unknown. This study aimed to identify the intrinsic molecular...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nakamura, Takuya, Shinriki, Satoru, Jono, Hirofumi, Guo, Jianying, Ueda, Mitsuharu, Hayashi, Mitsuhiro, Yamashita, Satoshi, Zijlstra, Andries, Nakayama, Hideki, Hiraki, Akimitsu, Shinohara, Masanori, Ando, Yukio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359213/
https://ncbi.nlm.nih.gov/pubmed/25504440
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