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Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble

Tau is an intrinsically disordered protein (IDP) whose primary physiological role is to stabilize microtubules in neuronal axons at all stages of development. In Alzheimer's and other tauopathies, tau forms intracellular insoluble amyloid aggregates known as neurofibrillary tangles, a process t...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Zhu, Shaolong, Shala, Agnesa, Bezginov, Alexandr, Sljoka, Adnan, Audette, Gerald, Wilson, Derek J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359001/
https://ncbi.nlm.nih.gov/pubmed/25767879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120416
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