Modulation of Cell Metabolic Pathways and Oxidative Stress Signaling Contribute to Acquired Melphalan Resistance in Multiple Myeloma Cells

Alkylating agents are widely used chemotherapeutics in the treatment of many cancers, including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian cancer. Melphalan is the most commonly used chemotherapeutic agent against multiple myeloma. However, despite a 70–80% initial respo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zub, Kamila Anna, de Sousa, Mirta Mittelstedt Leal, Sarno, Antonio, Sharma, Animesh, Demirovic, Aida, Rao, Shalini, Young, Clifford, Aas, Per Arne, Ericsson, Ida, Sundan, Anders, Jensen, Ole Nørregaard, Slupphaug, Geir
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358942/
https://ncbi.nlm.nih.gov/pubmed/25769101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119857
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