An Inverse Switch in DNA Base Excision and Strand Break Repair Contributes to Melphalan Resistance in Multiple Myeloma Cells

Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance. Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 multiple myeloma cells and its Melphalan-resistant derivative 8226-LR5. We o...

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Detalhes bibliográficos
Main Authors: Sousa, Mirta M. L., Zub, Kamila Anna, Aas, Per Arne, Hanssen-Bauer, Audun, Demirovic, Aida, Sarno, Antonio, Tian, Erming, Liabakk, Nina B., Slupphaug, Geir
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566207/
https://ncbi.nlm.nih.gov/pubmed/23405159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055493
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