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Declining transition/transversion ratios through time reveal limitations to the accuracy of nucleotide substitution models

BACKGROUND: Genetic analyses of DNA sequences make use of an increasingly complex set of nucleotide substitution models to estimate the divergence between gene sequences. However, there is currently no way to assess the validity of nucleotide substitution models over short time-scales and with limit...

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Bibliografiske detaljer
Udgivet i:BMC Evol Biol
Main Authors: Duchêne, Sebastián, Ho, Simon YW, Holmes, Edward C
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358783/
https://ncbi.nlm.nih.gov/pubmed/25886870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-015-0312-6
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