A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

We performed a genome-scale shRNA screen for modulators of B-cell leukemia progression in vivo. Results from this work revealed dramatic distinctions between the relative effects of shRNAs on the growth of tumor cells in culture versus in their native microenvironment. Specifically, we identified ma...

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Enregistré dans:
Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Meacham, Corbin E., Lawton, Lee N., Soto-Feliciano, Yadira M., Pritchard, Justin R., Joughin, Brian A., Ehrenberger, Tobias, Fenouille, Nina, Zuber, Johannes, Williams, Richard T., Young, Richard A., Hemann, Michael T.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2015
Sujets:
Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358400/
https://ncbi.nlm.nih.gov/pubmed/25737277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.254151.114
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