Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution

Precise control of protein turnover is essential for cellular homeostasis. The ubiquitin-proteasome system is well established as a major regulator of protein degradation, but an understanding of how inherent structural features influence the lifetimes of proteins is lacking. We report that yeast, m...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: van der Lee, Robin, Lang, Benjamin, Kruse, Kai, Gsponer, Jörg, Sánchez de Groot, Natalia, Huynen, Martijn A., Matouschek, Andreas, Fuxreiter, Monika, Babu, M. Madan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358326/
https://ncbi.nlm.nih.gov/pubmed/25220455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.055
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