Mechanism of N-Acylthiourea-mediated Activation of Human Histone Deacetylase 8 (HDAC8) at Molecular and Cellular Levels

We reported previously that an N-acylthiourea derivative (TM-2-51) serves as a potent and isozyme-selective activator for human histone deacetylase 8 (HDAC8). To probe the molecular mechanism of the enzyme activation, we performed a detailed account of the steady-state kinetics, thermodynamics, mole...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Singh, Raushan K., Cho, Kyongshin, Padi, Satish K. R., Yu, Junru, Haldar, Manas, Mandal, Tanmay, Yan, Changhui, Cook, Gregory, Guo, Bin, Mallik, Sanku, Srivastava, D. K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
Onderwerpen:
Enzymology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358293/
https://ncbi.nlm.nih.gov/pubmed/25605725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.600627
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